PhD in Cancer Bioinformatics

Job No: G122
Location: Darlinghurst, Sydney

Project: Single cell gene expression studies of breast cancer heterogeneity

Supervisor: Dr Alex Swarbrick

Background: The analysis of cancer genomes and transcriptomes over the past decade has led to remarkable insights into the stratification of cancer into subtypes and identified new therapeutic targets for personalised treatment.   However, these methods measure the average signal from millions of cells and in doing so assume cancers to be homogenous.

Recent evidence proves that, to the contrary, heterogeneity is a pervasive feature of breast cancers.  

We hypothesise that understanding the causes and consequences of this heterogeneity will provide astonishing new insights into cancer development, metastasis and drug response.

We are using cutting edge new methods to study the transcriptomes of single cells purified from tumours in high throughput. We will use these tools to understand the drivers of cellular heterogeneity and the impact that heterogeneity has on metastatic growth and therapeutic response. Ultimately we hope to develop new therapeutic strategies to treat metastatic disease.

We are looking for an enthusiastic applicant with a background in computer science, maths, statistics or bioinformatics to join our multidisciplinary team of biologists, oncologists, pathologists and bioinformaticians.

 

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