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PhD Project: Novel therapeutic strategies for treatment resistant Breast Cancer

Job No: G58

Location: Darlinghurst, Sydney

Closing Date: 12 Sep 2022 AEST

The natural history of breast cancer has been altered with new therapeutic strategies, resulting in improved survival rates, but also new patterns of treatment resistance.

This PhD project is focussed on better understanding treatment resistance to endocrine therapies and CDK4/6 inhibitors. Using established therapy sensitive, resistant and genomically modified cell line models, 3D tumour tissue organoid models that retain an intact tumour microenvironment for high throughput drug screening and Patient Derived Xenograft (PDX) models, we will dissect the biological drivers of resistance, and evaluate new therapies and biomarkers in this context.

This project is highly translational in nature and aims to establish critical preclinical proof of concept data to bring novel therapy concepts into clinical trials.

Supervisors:

Elgene Lim see Professor Elgene Lim Profile

Liz Caldon See Associate Professor Liz Caldon profile

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PhD Project: Novel therapeutic strategies for treatment resistant Breast Cancer

Job No: G58 Location: Darlinghurst, Sydney Closing Date: 12 Sep 2022 AEST

Personal Details * Required field

Questions

Job No: G58

Location: Darlinghurst, Sydney

Closing Date: 12 Sep 2022 AEST